CFO-Type Designs in Phase I/II Clinical Trials


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Documentation for package ‘CFO’ version 2.2.0

Help Pages

aCFO.next Determination of the dose level for next cohort in the accumulative calibration-free odds (aCFO) design for phase I trials
CFO.next Determination of the dose level for next cohort in the calibration-free odds (CFO) design for phase I trials
CFO.oc Generate operating characteristics of phase I trials single-drug trials in multiple simulations
CFO.selectmtd Select the maximum tolerated dose (MTD) for the real single-drug trials
CFO.simu Conduct one simulation using the calibration-free odds (CFO), accumulative CFO (aCFO) design, or randomized CFO (rCFO) design for phase I trials.
CFO2d.next Determinate the dose level for the next cohort in the two-dimensional calibration-free odds (2dCFO) design for phase I trials.
CFO2d.oc Generate operating characteristics of phase I drug-combination trials in multiple simulations
CFO2d.selectmtd Select the maximum tolerated dose (MTD) for the real drug combination trials
CFO2d.simu Conduct one simulation using the two-dimensional calibration-free odds (2dCFO) design for phase I trials.
CFOeff.next Determination of the dose level for next cohort in the calibration-free odds (CFO) design for phase I/II trials
CFOeff.oc Generate operating characteristics of phase I/II trials single-drug trials in multiple simulations.
CFOeff.selectobd Select the optimal biological dose (OBD) for the real single-drug trials
CFOeff.simu Conduct one simulation using the calibration-free odds (CFO) design for phase I/II trials
gammatable Generating table of threshold gamma_L and gamma_R in the calibration-free odds (CFO) design
lateonset.next Determination of the dose level for next cohort in the calibration-free odds type (CFO-type) design with late-onset toxicity for phase I trials
lateonset.simu Conduct one simulation using the calibration-free odds type (CFO-type) design with late-onset toxicity for phase I trials.
pCFO.next Determination of the dose level for next cohort in the precision calibration-free odds (pCFO) design for phase I trials
plot.cfo Plot the results by other functions
print.cfo Generate descriptive summary for objects returned by other functions
rCFO.next Determination of the dose level for next cohort in the randomized calibration-free odds (rCFO) design for phase I trials
summary.cfo Generate descriptive summary for objects returned by other functions