Fisher information matrix

Fixed effects

\(\mu_{C50}\) \(\mu_{Cl}\) \(\mu_{ka}\) \(\mu_{kout}\) \(\mu_{Rin}\) \(\mu_{V}\)
\(\mu_{C50}\) 70.0664219 151.4935 0.7953132 -919.8695 13.5329397 0.4559782
\(\mu_{Cl}\) 151.4934518 20239.9250 50.4863028 1534.7901 17.8048013 120.9719105
\(\mu_{ka}\) 0.7953132 50.4863 11.5631987 -24.0005 0.0523819 -2.8242142
\(\mu_{kout}\) -919.8695279 1534.7901 -24.0005029 244789.5742 -424.5229720 -307.6711558
\(\mu_{Rin}\) 13.5329397 17.8048 0.0523819 -424.5230 4.9705644 0.2086126
\(\mu_{V}\) 0.4559782 120.9719 -2.8242142 -307.6712 0.2086126 10.8418471

Variance effects

\(\omega^2_{C50}\) \(\omega^2_{Cl}\) \(\omega^2_{ka}\) \(\omega^2_{kout}\) \(\omega^2_{Rin}\) \(\omega^2_{V}\) \({\sigma_{inter}}_{RespPK}\) \({\sigma_{slope}}_{RespPK}\) \({\sigma_{inter}}_{RespPD}\)
\(\omega^2_{C50}\) 159.0614326 8.726839 0.0364333 6.853896e+01 120.1584537 0.2993992 2.866087 14.604699 11.1070184
\(\omega^2_{Cl}\) 8.7268386 1828.147507 1.7230339 2.239274e+00 2.4410041 247.3180328 108.163532 411.591440 3.8667050
\(\omega^2_{ka}\) 0.0364333 1.723034 13.6916546 8.294750e-02 0.0032004 20.4190359 13.045806 21.699715 0.0149539
\(\omega^2_{kout}\) 68.5389558 2.239274 0.0829475 1.213419e+04 295.6054511 340.7815443 220.152518 1040.569092 74.9995549
\(\omega^2_{Rin}\) 120.1584537 2.441004 0.0032004 2.956055e+02 328.2513185 1.2690209 1.945182 10.899664 0.7619013
\(\omega^2_{V}\) 0.2993992 247.318033 20.4190359 3.407815e+02 1.2690209 7522.9215037 391.424238 923.510446 6.9667597
\({\sigma_{inter}}_{RespPK}\) 2.8660874 108.163532 13.0458059 2.201525e+02 1.9451821 391.4242378 1100.570373 2286.413153 0.9489350
\({\sigma_{slope}}_{RespPK}\) 14.6046990 411.591440 21.6997146 1.040569e+03 10.8996638 923.5104458 2286.413153 5507.480011 2.6647957
\({\sigma_{inter}}_{RespPD}\) 11.1070184 3.866705 0.0149539 7.499955e+01 0.7619013 6.9667597 0.948935 2.664796 22.1525498

Correlation matrix

Fixed effects

\(\mu_{C50}\) \(\mu_{Cl}\) \(\mu_{ka}\) \(\mu_{kout}\) \(\mu_{Rin}\) \(\mu_{V}\)
\(\mu_{C50}\) 1.0000000 -0.1186007 -0.0159886 -0.0789157 -0.7083302 0.0167060
\(\mu_{Cl}\) -0.1186007 1.0000000 -0.1855305 -0.1052588 0.0209492 -0.3109745
\(\mu_{ka}\) -0.0159886 -0.1855305 1.0000000 0.0858011 0.0312870 0.3009245
\(\mu_{kout}\) -0.0789157 -0.1052588 0.0858011 1.0000000 0.3322880 0.2252293
\(\mu_{Rin}\) -0.7083302 0.0209492 0.0312870 0.3322880 1.0000000 0.0414373
\(\mu_{V}\) 0.0167060 -0.3109745 0.3009245 0.2252293 0.0414373 1.0000000

Variance effects

\(\omega^2_{C50}\) \(\omega^2_{Cl}\) \(\omega^2_{ka}\) \(\omega^2_{kout}\) \(\omega^2_{Rin}\) \(\omega^2_{V}\) \({\sigma_{inter}}_{RespPK}\) \({\sigma_{slope}}_{RespPK}\) \({\sigma_{inter}}_{RespPD}\)
\(\omega^2_{C50}\) 1.0000000 -0.0072107 -0.0017481 0.0725937 -0.5368103 0.0047772 0.0272335 -0.0325961 -0.2225230
\(\omega^2_{Cl}\) -0.0072107 1.0000000 -0.0089835 0.0398845 -0.0017065 -0.0502213 0.1256295 -0.1616533 -0.0209663
\(\omega^2_{ka}\) -0.0017481 -0.0089835 1.0000000 -0.0036494 0.0010070 -0.0519558 -0.0885031 0.0561229 0.0013846
\(\omega^2_{kout}\) 0.0725937 0.0398845 -0.0036494 1.0000000 -0.1641948 -0.0186550 0.1639297 -0.1986591 -0.1591852
\(\omega^2_{Rin}\) -0.5368103 -0.0017065 0.0010070 -0.1641948 1.0000000 0.0002165 -0.0256381 0.0312109 0.1303492
\(\omega^2_{V}\) 0.0047772 -0.0502213 -0.0519558 -0.0186550 0.0002165 1.0000000 -0.0117462 -0.0364945 -0.0130593
\({\sigma_{inter}}_{RespPK}\) 0.0272335 0.1256295 -0.0885031 0.1639297 -0.0256381 -0.0117462 1.0000000 -0.9297097 -0.0288042
\({\sigma_{slope}}_{RespPK}\) -0.0325961 -0.1616533 0.0561229 -0.1986591 0.0312109 -0.0364945 -0.9297097 1.0000000 0.0339147
\({\sigma_{inter}}_{RespPD}\) -0.2225230 -0.0209663 0.0013846 -0.1591852 0.1303492 -0.0130593 -0.0288042 0.0339147 1.0000000

Determinant, condition numbers and D-criteria of the FIM

Determinant
Condition numbers
D-criterion
8.754861e+37 121271.2 921.2336 338.4412

Values for SE and RSE

Value SE RSE (%)
\(\mu_{C50}\) 1.2000000 0.1755812 14.631765
\(\mu_{Cl}\) 0.1300000 0.0075104 5.777242
\(\mu_{ka}\) 1.6000000 0.3101871 19.386696
\(\mu_{kout}\) 0.0600000 0.0022586 3.764318
\(\mu_{Rin}\) 5.4000000 0.6921302 12.817226
\(\mu_{V}\) 8.0000000 0.3374586 4.218233
\(\omega^2_{C50}\) 0.1000000 0.0957198 95.719795
\(\omega^2_{Cl}\) 0.2449490 0.0238145 9.722214
\(\omega^2_{ka}\) 0.8366600 0.2725700 32.578349
\(\omega^2_{kout}\) 0.1000000 0.0095087 9.508701
\(\omega^2_{Rin}\) 0.4472136 0.0661654 14.795027
\(\omega^2_{V}\) 0.1414214 0.0116845 8.262156
\({\sigma_{inter}}_{RespPK}\) 0.6000000 0.0833497 13.891619
\({\sigma_{slope}}_{RespPK}\) 0.0700000 0.0376493 53.784670
\({\sigma_{inter}}_{RespPD}\) 4.0000000 0.2204041 5.510103