Power and Sample Size Based on Two One-Sided t-Tests (TOST) for (Bio)Equivalence Studies

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Documentation for package ‘PowerTOST’ version 1.3-5

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

Help Pages

bib.CL	Design matrices of period balanced incomplete block designs
CI.BE	1-2*alpha confidence interval given point estimator, CV and n
CI.RatioF	1-2*alpha Fieller confidence interval given point est., CV (,CVb) and n
CI2CV	CV from a given Confidence interval
ct5.1	Sample size tables for the classical 2x2 crossover
ct5.2	Sample size tables for the classical 2x2 crossover
ct5.3	Sample size tables for the classical 2x2 crossover
ct5.4.1	Sample size tables for the classical 2x2 crossover
ct9.6.2	Sample size tables for the 2x2x3 replicate crossover
ct9.6.4	Sample size tables for the 2x4x4 replicate crossover
ct9.6.6	Sample size tables for the 2x2x3 replicate crossover
ct9.6.8	Sample size tables for the 2x4x4 replicate crossover
ctCW.III	Sample size tables for the parallel group design
ctSJ.VIII.10	Sample size tables for the parallel group design
ctSJ.VIII.20	Sample size tables for the parallel group design
CV2mse	Helper functions
CV2se	Helper functions
CVCL	Confidence limits of a CV for log-normal data
CVfromCI	CV from a given Confidence interval
CVp2CV	Decompose CV(T) and CV(R) from 'pooled' CV of T/R
CVpooled	Pooled CV from several studies
data2x2	Sample size tables for the classical 2x2 crossover
data2x2x3	Sample size tables for the 2x2x3 replicate crossover
data2x4x4	Sample size tables for the 2x4x4 replicate crossover
data_parallel	Sample size tables for the parallel group design
exppower.noninf	'Expected' power of non-inferiority test
exppower.TOST	'Expected' power of TOST procedure
expsampleN.noninf	Sample size based on 'expected' power for the non-inferiority test
expsampleN.TOST	Sample size based on 'expected' power
known.designs	Show the 'known' designs
mse2CV	Helper functions
OwensQ	Owen's Q-function
OwensQOwen	Owen's Q-function via repeated integration by parts
OwensT	Owen's T-function
pa.ABE	Power analysis for average bioequivalence (ABE)
pa.NTIDFDA	Power analysis for scaled ABE for NTID according to FDA
pa.scABE	Power analysis for scaled average bioequivalence (scABE)
plot.pwrA	Power analysis for average bioequivalence (ABE)
power.2TOST	Power for two simultaneous TOST procedures
power.dp	Power of dose-proportionality studies evaluated via Power model
power.HVNTID	(Empirical) Power for BE decision via FDA method for highly variable NTID's
power.noninf	Power of the one-sided non-inferiority t-test
power.NTIDFDA	(Empirical) Power for BE decision via FDA method for NTID's
power.RatioF	Power for equivalence of the ratio of two means with normality on original scale
power.RSABE	(Empirical) Power for BE decision via linearized scaled ABE criterion
power.scABEL	(Empirical) Power for BE decision via scaled (widened) BE acceptance limits
power.TOST	Power of the classical TOST procedure
power.TOST.sim	Power of the TOST procedure obtained via simulations
print.CVp	Pooled CV from several studies
print.pwrA	Power analysis for average bioequivalence (ABE)
pvalue.TOST	p-value(s) of the TOST procedure
pvalues.TOST	p-value(s) of the TOST procedure
sampleN.2TOST	Sample size based on power of 2 TOSTs
sampleN.dp	Sample size estimation of dose-proportionality studies evaluated via Power model
sampleN.HVNTID	Sample size estimation for BE decision via FDA method for highly variable (HV) narrow therapeutic index drugs (NTID's)
sampleN.noninf	Sample size for the non-inferiority t-test
sampleN.NTIDFDA	Sample size estimation for BE decision via FDA method for narrow therapeutic index drugs (NTID's)
sampleN.RatioF	Sample size for equivalence of the ratio of two means with normality on original scale
sampleN.RSABE	Sample size estimation for BE decision via linearized scaled ABE criterion
sampleN.scABEL	Sample size estimation for BE decision via scaled (widened) BE acceptance limits
sampleN.scABEL.ad	Sample size estimation for ABEL and iteratively adjusted alpha
sampleN.TOST	Sample size based on power of TOST
scABEL	Helper function to calculate the (widened) scaled BE acceptance limits
scABEL.ad	Iteratively adjusted alpha for ABEL
se2CV	Helper functions
type1error.2TOST	Type I error rate for two simultaneous TOST procedures